New NGS panel supports faster, more efficient identification and analysis of myeloid disorders
Oxford and Cambridge, UK – 18 June 2015 – Oxford Gene Technology (OGT), the molecular genetics company, today announces the launch of the SureSeq™ Myeloid Panel, a highly sensitive next generation sequencing (NGS) panel able to detect mutational changes in 25 genes in one comprehensive assay. The panel replaces the existing procedure of sequential analysis of single genes, to reduce the time and cost associated with identifying myeloproliferative neoplasms (MPNs), a group of diseases that cause abnormal blood cell production.
Combined with OGT’s Cytocell fluorescence in situ hybridisation (FISH) probes, the panel is part of a complete solution for understanding the causes of myeloid disease. FISH probes can be used as a first molecular technique to rule out chronic myeloid leukaemia (CML) and other confounding disorders, after which, the SureSeq Myeloid panel can be used instead of existing sequential single-gene assays to further research the genetic causes of the disease.
The highly sensitive panel overcomes the challenges posed by heterogeneous samples, which may contain very low quantities of causative genetic variants. Research has validated the panel to accurately detect alleles down to 1% minor allele fraction (MAF) at a read depth of >1000x. OGT has worked closely with cancer experts including Professor Nick Cross (Director of the Wessex National Genetics Reference Laboratory, UK) and Mike Griffiths (Consultant Clinical Scientist at West Midlands Regional Genetics Laboratory, UK) to define the most up-to-date gene content for the panel.
Professor Nick Cross commented, “Currently the genetic characterisation of MPNs and related hereditary conditions can be time consuming and complex. The SureSeq panel should allow research into these disorders to become a much more standard procedure.”
Mike Evans, CEO of OGT commented, “Our SureSeq Myeloid Panel is part of OGT’s expanding NGS portfolio for cancer research, demonstrating OGT’s commitment to this important field. We look forward to announcing further new product developments, aimed at enhancing cancer detection and improving the laboratory workflow, over the next few months.”
About Oxford Gene Technology
Oxford Gene Technology (OGT) provides world-class genetics research solutions to leading clinical and academic research institutions. Founded by Professor Sir Edwin Southern, and with customers in over 60 countries, OGT has a strong reputation and increasing share in the large and growing genomic medicine market. The Company’s Cytocell®, CytoSure™, SureSeq™ and Genefficiency™ range of fluorescence in situ hybridisation (FISH), microarray and next generation sequencing (NGS) products and services deliver high-quality genetic analysis, enabling accurate identification and confirmation of the causative variation underlying genetic disease.
For more information on the Company, please visit our website at www.ogt.com.
CytoSure™, SureSeq™ and Genefficiency™ NGS browser/report: For Research Use Only; Not for Use in Diagnostic Procedures. Cytocell: Some products may not be available in the US.
About Myeloproliferative Neoplasms
Myeloproliferative neoplasms (MPNs) are a group of diseases that affect normal blood cell production in the bone marrow resulting in overproduction of one or more cell types (i.e. red cells, white cells or platelets). There are numerous different sub-types of MPNs that are distinguished from each other by the type of cell which is most affected and the genetic profile. The incidence of MPN is around 5/100,000/year. Around half of these are Chronic Myeloid Leukaemia (CML). Approximately 60% of patients are male, with a typical age of onset of 40-60 years.
Issued for and on behalf of Oxford Gene Technology by Instinctif Partners.
For more information please contact: OGT@instinctif.com
Sue CharlesManaging Partner