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Crescendo Biologics appoints Dr Kenji Hashimoto as Chief Medical Officer

Crescendo Biologics appoints Dr Kenji Hashimoto as Chief Medical Officer

Cambridge, UK, 3 February 2020 – Crescendo Biologics Ltd (Crescendo), the drug developer of novel, targeted, T cell enhancing therapeutics, today announces the appointment of Dr Kenji Hashimoto as the Company’s Chief Medical Officer (CMO).

Dr Hashimoto will oversee Crescendo’s clinical development strategy and medical affairs.  His appointment marks the next stage of Crescendo’s development, as it focuses on building out its clinical capabilities and bringing its lead programme, CB307, to the clinic later this year. He replaces Dr Pavel Pisa as CMO, who has transitioned into the role of scientific adviser.

Dr Hashimoto joins the Company with over 15 years’ experience in oncology and immuno-oncology. Prior to joining Crescendo, he led the clinical development of a checkpoint inhibitor in renal cell carcinoma at Roche, with responsibility for multiple late phase clinical trials.  Prior to that, he was Clinical Research Physician at Chugai Pharma Europe, leading clinical development for a bispecific
T cell engaging antibody programme as well as other early phase projects. He was previously Chief Resident in Medical Oncology at the National Cancer Centre Hospital, Tokyo. He has a PhD in medical oncology from the University of Oxford and a medical degree from Gunma University in Japan.

The Company’s lead programme, CB307, is a CD137 (4-1BB) x PSMA bispecific for PSMA-positive tumours.

Theodora Harold, CEO of Crescendo Biologics, said:

“Kenji has considerable immuno-oncology expertise and an impressive track record in leading clinical development programmes. This experience will be crucial as we progress our pipeline of innovative, first in class, T cell enhancing programmes. On behalf of the Board, I would like to welcome Kenji to the Crescendo team at this exciting time for the Company as we take our first programme into the clinic later this year.

“I would also like to thank Pavel for his valuable contribution to the Company as CMO and look forward to working with him as one of our scientific advisers.”

Kenji Hashimoto, CMO of Crescendo Biologics commented:

“I am delighted to be joining Crescendo at this exciting time. Crescendo has established an important position in the CD137 (4-1BB) space. I look forward to helping the Company advance its pipeline of novel T cell enhancing programmes, and to helping translate its next generation programmes into therapeutics for real patient benefit.”

About Crescendo Biologics

Crescendo Biologics is a T cell enhancing company. Crescendo develops potent, truly differentiated Humabody® VH therapeutics with a focus on innovative, targeted T cell approaches in oncology.

Leading its proprietary pipeline, Crescendo Biologics has developed CB307, a novel CD137 (4-1BB)
x PSMA bispecific, targeting PSMA-positive tumours for the selective activation of tumour-specific T cells exclusively within the tumour microenvironment. CB307 is designed to achieve a longer lasting anti-cancer effect whilst avoiding systemic toxicity and is on track to enter the clinic in 2020. The company has a broad portfolio of additional Humabody products in preclinical development as well as a strategic partnership with Takeda Pharmaceuticals, where three Humabody products are currently advancing towards the clinic.

The Company’s ability to develop multi-functional Humabody® VH therapeutics is based on its unique, patent protected, transgenic mouse platform generating 100% human VH domain building blocks (Humabody® VH). These robust molecules can be configured to engage therapeutic targets in such a way that they deliver novel biology and superior bio-distribution. This results in larger therapeutic windows compared to conventional IgG approaches. Humabody®-based formats can be applied across a range of indications beyond cancer.

Crescendo Biologics is a private company located in Cambridge, UK, and is backed by blue-chip investors including Sofinnova Partners, Andera Partners, IP Group, Takeda Ventures, Quan Capital and Astellas.

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Issued for and on behalf of Crescendo Biologics Ltd by Instinctif Partners.
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